Evidence-based TDM for antiretroviral drugs

Current antiretroviral drugs for human immunodeficiency virus infection: review article

Currently, there are about 37 million people worldwide living with human immunodeficiency virus (HIV) /AIDS, with an estimated two million new cases per year globally. According to estimates from the World Health Organization (WHO), only 75% of the population with HIV know their status. Initially, HIV infection was associated with significantly increased rates of mortality and morbidity. Howeve...

[Pharmacogenetics of antiretroviral drugs].

Clinical Guidelines: Antiretroviral Drugs for Hiv Prevention

On antiretroviral guidelines and evidence based medicine.

individual patients, and that they are not the “Ten Commandments” written in stone. Decisions about the care of individual patients can not be purely based in a set of guidelines, even if they are based in the “sacrosanct” principles of evidence based medicine (EBM). EBM has its own limitations and optimal care of the individual patient still relies in other forms of knowledge that are not obta...

Development of mass spectrometric methods for the quantitation of drugs of abuse and therapeutic drugs (DAT/TDM) in clinical samples

This study focuses on the quantitative analysis of the cardiac glycosidedrug digitoxin and its three main metabolites digitoxigenin-bisdigitoxose, digitoxigenin-monodigitoxose, and digitoxigenin using electrospray ionization-differential ion mobilityspectrometry-tandem mass spectrometry (ESI-DMS-MS/MS). Despite large molecularweight differences, gas-phase separation of the four ...